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KMID : 0363220090470030375
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Korean Journal of Dermatology
2009 Volume.47 No. 3 p.375 ~ p.377
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Amiodarone Induced Blue-gray Pigmentation
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Cho Eun-Ah
Kang Hoon
Lee Seung-Dong
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Abstract
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Amiodarone (AD) is a benzofuran derivative that has been used for the treatment of recurrent arrhythmia and as a coronary vasodilator in Europe since 1964. AD-related hyperpigmentation develops after an average of 20 months of continuous AD treatment and with a minimal total dose of 160 g AD in less than 10% of the patients. A 49-year-old man presented with asymptomatic blue-gray patches that had slowly developed on the face over the previous 3 months. He had been taken amiodarone continuously for 39 months (cumulative dose: 974 g). A skin lesion biopsy from the face showed many dermal melanophages containing brown granules. The AD was discontinued and he begin using sunscreen and is courrently being followed-up. The skin discoloration was still evident, but slightly diminished at five month’s follow up
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KEYWORD
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Amiodarone, Blue-gray pigmentation, Hyperpigmentation
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